Product Name :
Levocetirizine Dihydrochloride
Description:
Levocetirizine (Xyzal, (-)-Cetirizine) is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.
CAS:
130018-87-0
Molecular Weight:
461.81
Formula:
C21H27Cl3N2O3
Chemical Name:
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
Smiles :
Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C1C=CC=CC=1)C1C=CC(Cl)=CC=1
InChiKey:
PGLIUCLTXOYQMV-UHFFFAOYSA-N
InChi :
InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Vitamin D2} MedChemExpress|{Vitamin D2} Vitamin D Related/Nuclear Receptor|{Vitamin D2} Protocol|{Vitamin D2} In Vitro|{Vitamin D2} custom synthesis|{Vitamin D2} Epigenetic Reader Domain}
Additional information:
Levocetirizine (Xyzal, (-)-Cetirizine) is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.|Product information|CAS Number: 130018-87-0|Molecular Weight: 461.81|Formula: C21H27Cl3N2O3|Chemical Name: 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride|Smiles: Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C1C=CC=CC=1)C1C=CC(Cl)=CC=1|InChiKey: PGLIUCLTXOYQMV-UHFFFAOYSA-N|InChi: InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).{{Ivosidenib} web|{Ivosidenib} Isocitrate Dehydrogenase (IDH)|{Ivosidenib} Protocol|{Ivosidenib} In Vitro|{Ivosidenib} supplier|{Ivosidenib} Epigenetics} 92 mg/mL(199.PMID:23847952 21 mM). 92 mg/mL(199.21 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Levocetirizine is a selective antihistaminic that acts through H1 receptor. Levocetirizine inhibits eotaxin-induced eosinophil transendothelial migration through monolayers of human dermal or lung microvascular endothelial cells in vitro. The drug also inhibits both resting and granulocyte-macrophage colony-stimulating factor (GM-CSF)-stimulated eosinophil adhesion to vascular cell adhesion molecule-1 (VCAM-1), eotaxin production by endothelial cells and ICAM-1, as well as major histocompatability complex (MHC) class I expression by interferon (IFN)-γ-stimulated keratinocytes.|In Vivo:|In vivo, levocetirizine has rapid absorption and high bioavailability, a low potential for drug interactions, low-volume distribution and a lack of effects on cognition, psychomotor function or the cardiovascular system. Levocetirizine improves renal function in diabetic rat. It attenuates the elevated renal levels of TNF-α and TGF-β1, ameliorates renal oxidative stress and restores NO bioavailability in diabetic kidney. Levocetirizine elicits vasculoprotective and renoprotective effects in experimental diabetes.|Products are for research use only. Not for human use.|
