Share this post on:

, et al. Hyperphagia and early-onset obesity as a result of a novel homozygous missense mutation in prohormone convertase 1/3. J Clin Endocrinol Metab. 2007; 92:33693. [PubMed: 17595246] 9. Benzinou M, Creemers JW, Choquet H, et al. Typical nonsynonymous variants in PCSK1 confer danger of obesity. Nature Genetics. 2008; 40:943. [PubMed: 18604207] 10. Zhu X, Zhou A, Dey A, et al. Disruption of PC1/3 expression in mice causes dwarfism and various neuroendocrine peptide processing defects. Proc Natl Acad Sci U S A. 2002; 99:10293. [PubMed: 12145326] 11. Lloyd DJ, Bohan S, Gekakis N. Obesity, hyperphagia and enhanced metabolic efficiency in Pc1 mutant mice. Hum Mol Genet. 2006; 15:18843. [PubMed: 16644867] 12. Vindrola O, Lindberg I. Biosynthesis in the prohormone convertase mPC1 in AtT-20 cells.Bombykol Biological Activity Mol Endocrinol. 1992; 6:10884. [PubMed: 1508222] 13. Hoshino A, Kowalska D, Jean F, et al. Modulation of PC1/3 activity by self-interaction and substrate binding.Ferroquine Protocol Endocrinology. 2011; 152:14021. [PubMed: 21303942] 14. Gradwohl G, Dierich A, LeMeur M, et al. neurogenin3 is expected for the development in the four endocrine cell lineages from the pancreas. Proc Natl Acad Sci USA. 2000; 97:1607611. [PubMed: 10677506] 15. Creemers JWM, Choquet H, Stijnen P, et al. Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute To Human Obesity. Diabetes. 2012; 61:38390. [PubMed: 22210313] 16. Henrich S, Lindberg I, Bode W, et al. Proprotein convertase models primarily based on the crystal structures of furin and kexin: explanation of their specificity. J Mol Biol. 2005; 345:2117. [PubMed: 15571716] 17. Zhou A, Bloomquist BT, Mains RE. The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages inside a strict temporal order throughout proopiomelanocortin biosynthetic processing. J Biol Chem. 1993; 268:1763. [PubMed: 8380577] 18. Creemers JW, Pritchard LE, Gyte A, et al. Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to produce agouti-related protein (AGRP)83-132: interaction among AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3.PMID:24631563 Endocrinology. 2006; 147:16211. [PubMed: 16384863]NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptGastroenterology. Author manuscript; out there in PMC 2014 July 01.Mart et al.Page19. Brakch N, Rist B, Beck-Sickinger AG, et al. Function of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations. Biochemistry. 1997; 36:163090. [PubMed: 9405066] 20. Zhu X, Cao Y, Voogd K, et al. On the processing of proghrelin to ghrelin. J Biol Chem. 2006; 281:388670. [PubMed: 17050541] 21. Batterham RL, Cowley MA, Little CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002; 418:650. [PubMed: 12167864] 22. Boey D, Lin S, Karl T, et al. Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity. Diabetologia. 2006; 49:13600. [PubMed: 16680491] 23. Farooqi IS, Keogh JM, Yeo GS, et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med. 2003; 348:10855. [PubMed: 12646665] 24. Galanopoulou AS, Kent G, Rabbani SN, et al. Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role in the endoproteases furin, PC1, and PC2. J Biol Chem. 1993; 268:6041. [PubMed: 8095501] 25. Elias CF. Leptin action in pubertal improvement: current advances and unanswered questions.

Share this post on:

Author: Sodium channel