nds having a superior antioxidant capacity, that is directly connected to the phytochemical content. A.

nds having a superior antioxidant capacity, that is directly connected to the phytochemical content. A. mAChR5 drug hierochuntica (particularly aqueous extract) protects rats against CCl4 -induced oxidative stress and acute kidney injury, as evidenced by a considerable drop in MDA levels and enhanced GSH and SOD activity, at the same time as the cessation of biochemical and histological alterations inside the kidneys. The protective efficacy could arise from the antioxidant and free radical scavenging properties of the phenolic compounds present in the A. hierochuntica extracts. These traits enable to clarify the plant’s medicinal efficacy as a herbal medication. Much more investigation is needed to entirely describe the active principles within a. hierochuntica, and this study is meant to stimulate more comprehensive related investigation to provide enough information and recommendations for defining its mechanisms and secure doses.Author Contributions: Conceptualization, T.I.A., Y.M.A. and H.B.; methodology, investigation, H.B. and H.A.A.-R.; information curation, T.I.A. and Y.M.A.; writing–original draft preparation, review,Nutrients 2021, 13,13 ofand editing; H.B. and H.A.A.-R. All authors have study and agreed to the Published version on the manuscript. Funding: The researchers would prefer to thank the Deanship of Scientific Study, Qassim University, for funding the publication of this project. Institutional Critique Board Statement: Not applicable. Informed Consent Statement: Not applicable. Data Availability Statement: The data presented in this study are available on request in the corresponding author. Conflicts of Interest: The authors declare no conflict of interest.AbbreviationsABTS: 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); AOA: antioxidant activity; BHA: butylated hydroxyanisole; BHA: butylated hydroxyanisole; DPPH: 1,1-diphenyl-2-picryl hydrazine; dw: dry weight; GA: gallic acid; GAE: gallic acid equivalent; GSH: reduced-glutathione; HPLC-DAD: high-performance liquid chromatography diode array detection; KAE: A. hierochuntica aqueous extract; KEE: A. hierochuntica ethanolic extract; MDA: malonaldehyde; QE: quercetin equivalent; RAA: relative antioxidant activity; ROS: reactive oxygen species; RSA: radical scavenging activity; Se: selenium; SE: regular error; SOD: superoxide dismutase; TC: total carotenoids; TC: total carotenoids; TF: total flavonoids; TE: trolox equivalents; TFL: total flavonols; TPC: total phenolic compounds.
Received: 25 October 2021 Accepted: 15 November 2021 Published: 17 NovemberPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This short article is an open access report distributed beneath the terms and conditions in the Creative Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ four.0/).Cancer is a major result in of death worldwide, accounting for almost 10 million deaths in 2020. Among the procedures which have been created to treat cancer, chemotherapy is utilized primarily to treat metastatic cancer that cannot be eradicated with surgery or radiotherapy. Although chemotherapy will be the most helpful method to eradicate cancer, it involves many challenges such as evolution of multidrug resistance (MDR) in cancer cells, which includes altered drug activation as a result of metabolism and excretion, and increased repair of DNA damage caused by anti-cancer drugs. The key mechanism GlyT2 Molecular Weight underlying MDR is