Product Name :
Lesopitron dihydrochloride
Description:
Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.
CAS:
132449-89-9
Molecular Weight:
393.74
Formula:
C15H23Cl3N6
Chemical Name:
2-4-[4-(4-chloro-1H-pyrazol-1-yl)butyl]piperazin-1-ylpyrimidine dihydrochloride
Smiles :
Cl.Cl.ClC1C=NN(CCCCN2CCN(CC2)C2N=CC=CN=2)C=1
InChiKey:
RGDLQJUAYQRGBC-UHFFFAOYSA-N
InChi :
InChI=1S/C15H21ClN6.2ClH/c16-14-12-19-22(13-14)7-2-1-6-20-8-10-21(11-9-20)15-17-4-3-5-18-15;;/h3-5,12-13H,1-2,6-11H2;2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.Radotinib web
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.|Product information|CAS Number: 132449-89-9|Molecular Weight: 393.74|Formula: C15H23Cl3N6|Chemical Name: 2-4-[4-(4-chloro-1H-pyrazol-1-yl)butyl]piperazin-1-ylpyrimidine dihydrochloride|Smiles: Cl.Cl.ClC1C=NN(CCCCN2CCN(CC2)C2N=CC=CN=2)C=1|InChiKey: RGDLQJUAYQRGBC-UHFFFAOYSA-N|InChi: InChI=1S/C15H21ClN6.2ClH/c16-14-12-19-22(13-14)7-2-1-6-20-8-10-21(11-9-20)15-17-4-3-5-18-15;;/h3-5,12-13H,1-2,6-11H2;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.IL-6 Protein, HumanSource |Shelf Life: ≥12 months if stored properly.PMID:35091647 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In vitro binding and autoradiographic studies with [3H]8-OH-DPAT and [3H]Lesopitron as radioligands confirm that Lesopitron binds to 5-HT1A receptors in the rat brain with a relatively high affinity (pKi=7.35). As expected of a full agonist at postsynaptic 5-HT1A receptors, Lesopitron (IC50=125 nM) inhibits forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes to the same extent as 5-HT. Lesopitron inhibits the firing of serotoninergic neurons both in vitro (in brainstem slices, IC50=120 nM).|In Vivo:|Lesopitron inhibits the firing of serotoninergic neurons both in vivo (in chloral hydrate-anaesthetized rats, ID50=35 μg/kg i.v.). Lesopitron administered at a dose which induces anxiolytic behaviour in rats (30 μg/kg, i.p.) markedly reduces 5-HT levels (to 45% of the basal value) in cortical perfusates.|Products are for research use only. Not for human use.|
